Semaglutide is a synthetic peptide derived from the naturally occurring glucagon-like peptide-1 (GLP-1). GLP-1 is an incretin hormone, naturally secreted in the gastrointestinal tract, that stimulates insulin and suppresses glucagon secretion depending on glucose levels. As a GLP-1 receptor agonist, semaglutide was developed based on the body of knowledge gained from the development of liraglutide, but designed to have a longer half-life. The structural differences between GLP-1 and semaglutide reduce enzymatic degradation and promote albumin-binding, both of which increase the half-life of the peptide. Research Studies: Tachibana T. Glucagon-like peptide-1. In: Ando H, Ukena K, Nagata S, eds. Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research. 2nd ed. Elsevier; 2021:239-241. Knudsen LB, Lau J. The discovery and development of liraglutide and semaglutide. Front Endocrinol. 2019;10. doi: 10.3389/fendo.2019.00155. Nauck MA, Quast DR, Wefers J, Meier JJ. GLP-1 receptor agonists in the treatment of type 2 diabetes — state-of-the-art. Mol Metab. 2021;46. doi: 10.1016/j.molmet.2020.101102. Smits MM, Van Raalte DH. Safety of semaglutide. Front Endocrinol. 2021;12. doi: 10.3389/fendo.2021.645563 Chao AM, Tronieri JS, Amaro A, Wadden TA. Semaglutide for the treatment of obesity. Trends Cardiovasc Med. 2023;33:159-166. doi: 10.1016/j.tcm.2021.12.008 Christou GA, Katsiki N, Blundell J, Fruhbeck G, Kiortsis DN. Semaglutide as a promising antiobesity drug. Obes Rev. 2019;20(6):805-815. doi: 10.1111/obr.12839. Wang L, Wang N, Zhang W, Cheng X, Yan Z, Shao Gm, Wang X, Wang R, Fu C. Therapeutic peptides: current applications and future directions. Signal Transduct Target Ther. 2022;7(48). doi: 10.1038/s41392-022-00904-4 PLEASE NOTE , this is sold as a lyophilized powder and must be reconstituted using bacteriostatic water. The bacteriostatic water can be purchased on our site.  Syringes are also available in our store if you'd like to add those on to your order. Refrigeration required once reconstituted.